Is the binding of mistletoe lectins I and III a useful prognostic indicator in colorectal carcinoma?

Journal/Book: Eur. J. Surgical Oncol. 20, 648-652. 1994;

Abstract: A retrospective study on 127 patients with colorectal carcinoma wasperformed to evaluate the use of mistletoe lectins I and III as possibleprognostic indicators. Tissue sections were stained by a histochemicaltechnique using these lectins and the staining results correlated withsurvival. No correlation between survival and the presence of lectinbinding or non-binding was found. A lectin with the same monosaccharidespecificity as ML-III, Helix pomatia agglutinin, which was of prognosticsignificance in the same patient cohort in another study showed onWestern blot analysis a slightly different lectin binding patterntowards glycoproteins than the MLs. The results of this study indicatethat even subtle differences in the carbohydrate composition ofglycoconjugates which can be differentiated by lectins are of biologicalsignificance in terms of the metastatic spread of tumours. Author.

Keyword(s): BLOTTING-WESTERN

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