Pathophysiologie des metabolischen Syndroms

Author(s): W. , K.

Journal/Book: Ärztezeitschrift für Naturheilverfahren. 1994; 35/12: 872-879.

Abstract: The "metabolic syndrome" is defined as singificantly greater association of various cardiovascular risk factors such as diabetes mellitus type 2, dyslipidaemia, arterial hypertension and obesity as well as the preliminary stages of these conditions resulting from insulin resistance with compensatory hyperinsulinaemia. Insulin resistance with consecutive hyperinsulinaemia leads to hypertriglyceridaemia with concurrently lowered HDL cholesterol in the plasma, raises arterial blood pressure, by, among other things, raising intravascular volume and peritherap artherial vascular resistance and may have a potentially atherogenic effect, e.g. by influencing the proliferation of smooth muscle cells, cellular cholersrol metabolism and fibrinolysis. Obesity, in particular the android type, appears to aggravate the phenomena mentioned above. The pathogenetic mechanisms of insulin resistance are still little known, but it is clerly susally conditioned by a defect in insulin action at the cellular level.

Keyword(s): metabolischen Syndrom, Syndrom X, Insulinresistenz, Adipositas, Hypertonus, Dyslipoproteinämie

Zurück | Weiter