Bestimmung von hemmenden Neurotransmittern im Liquor nach Akupunktur oder Gabe von Morphin

Author(s): K. , T., N. , G. i., D. , R.

Journal/Book: Deutsche Zeitschrift für Akupunktur. 1994; 37/4: 77-82.

Abstract: The present study was to clarify how the concentrations of serotonin, noradrenaline and dopamine in the human XSF change after electroacupuncture or administration of morphine. 45 male patients with an average age of 62 years who had to undergo prostate resection were subdivided into three groups. In 15 patients, an electrostimulation of the acupunctur points Ma 36 was carried out with 2 Hz for 20 minutes. A further 15 patients received 10 mg morphine s.c. 30 minutes befor withdrawal of CSF. 15 patients were not pretreated (control group). In all patients, 2 ml of CSF were taken before spinal anaesthesia and deep-frozen immediately. The neurotransmitters noradrenaline, dopamine and serotonin were determined in the CSF. 1. In the patients who had been pretreated with morphine, appreciably higher noradrenalin-concertrations (x-median1508 vs. x-median 189,5) were shown compared to the control group. On the other hand, almost the same dopamine content was found, whereas the serotonin concentration was somewhat less (similar to that after acupuncture). 2. After acupuncture pretratment, the mean (x-median) dopamine levels were 5 times higher than in the non-pretreated persons (x-median 1268 vs. x-median 185,5). The concentrations of noradrenaline was largely the same, wheras the serotonin content was somewhat less Both electroacupuncture and morphine lead to alterations of neurotransmitter concentrations in the CSF. According to our investigations, the effect of electro-acupuncture in humans appears to be more likely attributable to dopaminergic than to a serotoninergic mechanism.

Keyword(s): Neurotransmitter im Liquor, Akupunktur.

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