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December 2019

Sheng Li Xue Bao. 1993 Feb; 45(1): 61-8.

[Effect of D1 and D2 dopamine receptor antagonists on acupuncture analgesia]

Wang HH, Xu SF.

Department of Neurobiology, Shanghai Medical University.

Some highly selective D1 or D2 receptor antagonists were tested on rabbit skin pain model to investigate the effect of the subtypes of dopamine receptor on acupuncture analgesia. It was found that iv. of D2 receptor antagonists haloperidol and clozapine, had a potentiating effect on acupuncture analgesia. Icv. of D2 receptor antagonists domperidone and sulpiride and D1 receptor antagonist SCH23390 also enhanced acupuncture analgesia markedly. The effect of D1 and D2 receptor on acupuncture analgesia was discussed.


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