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November 2022

Gastroenterol Clin Biol. 1993 ; 17(12): 959-62.

[Chronic active hepatitis and cirrhosis induced by wild germander. 3 cases]

Ben Yahia M, Mavier P, Métreau JM, Zafrani ES, Fabre M, Gatineau-Saillant G, Dhumeaux D, Mallat A.

Service de Gastroentérologie, Hôpital Farhat, Hached, Sousse, Tunisie.

We report 3 cases of chronic liver injury that were observed after prolonged treatment with wild germander, a herbal medicine recently prohibited by French Ministry of Health, following several reports suggesting its hepatotoxicity. Chronic active hepatitis was found in 2 cases, and active cirrhosis in 1 case. The onset of hepatitis occurred after 6 to 7 months of treatment. Serum anti-nuclear and anti-smooth muscle antibodies were present in 2 patients. In 2 cases, wild-germander involvement was recognized several months after appearance of liver injury. Following treatment discontinuation, outcome was favorable in the 3 patients. These observations suggest that diagnosis of acute or chronic liver injury of unknown origin should always include the search for herbal medicine treatment.

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