Molecular mechanism of inhibition of mammalian protein synthesis by some four-chain agglutinins. Proposal of an extended classification of plant ribosome-inactivating proteins (rRNA N-glycosidases)

Journal/Book: FEBS-Lett 329 (1-2), 59-62, ISSN: 0014-5793.. 1993;

Abstract: The four chain agglutinins from Abrus precatorius, Viscum album andRicinus communis promote depurination of the 28 S rRNA from rabbitreticulocyte ribosomes characteristic of the commonribosome-inactivating proteins (RIPs). These agglutinins inhibitedmammalian protein synthesis at nanomolar concentrations but they do notaffect plant protein synthesis under the same conditions. Therefore,they should also be considered as true RIPs but of a new class, thefour-chain RIPs. An extended classification of RIPs is presented basedon the former one from Stirpe et al. (Bio/technology 10 (1992) 405-412).Author.

Keyword(s): ANIMAL

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