Antitumorous and immunomodulatory effects of the VISCUM ALBUM L. preparation Isorel

Journal/Book: Oncology 50, 393-398. 1993;

Abstract: There are numerous data on the immunostimulative and antitumorousactivity of various Viscum album tissue extracts. Isorel (Novipharm,Austria) is one of these compounds. We found that in mice an increasednumber of plaque-forming cells to sheep red blood cells (SRBC) followedthe injection of Isorel together with SRBC. Further, survival time of aforeign skin graft was shortened if Isorel was applied at the correcttime. Finally, suppressed immune reactivity in tumorous mice recoveredfollowing Isorel injection. Isorel was further shown to be cytotoxic totumor cells in vitro. Its application to tumor-bearing mice couldprolong their life but without any therapeutic effect. However, acombination of local irradiation and Isorel was very effective:following 43 Gy of local irradiation to a transplantedmethylcholanthrene-induced fibrosarcoma (volume about 240 mm3) growingin syngeneic CBA/HZgr mice, the tumor disappeared in about 25% of theanimals; the addition of Isorel increased the incidence of cured animalsto over 65%. The combined action of Isorel, influencing tumor viabilityon the one hand and the host's immune reactivity on the other, seems tobe favorable for its antitumor action in vivo. Author.

Keyword(s): ANIMAL

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