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October 2022

Gastroenterol Clin Biol. 1992 ; 16(10): 798-800.

[Liver damage induced by the ingestion of a product of phytotherapy containing wild germander. Four cases]

Mattei A, Bizollon T, Charles JD, Debat P, Fontanges T, Chevallier M, Trepo C.

Service d'Hépato-Gastroentérologie, Hôtel-Dieu, Lyon.

We report 4 cases of patients who developed hepatic injury during administration of herbal medicines for loosing weight with Wild Germander. Three developed jaundice and one had fatigue. Aminotransaminase activities were increased in all patients. Outcome was favorable after drug withdrawal in all patients. Liver biopsy showed centrolobular necrosis and portal lymphoplasmocytic infiltration. Another drug than Wild Germander might have been implicated in hepatic injury in two patients. The similarity of these cases suggests, however, that Wild Germander, like other herbal medicines, may be responsible for hepatic injury.

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