J Pediatr. 1992 Nov; 121(5 Pt 1): 710-4.

Long-term neurologic consequences of nutritional vitamin B12 deficiency in infants.

Graham SM, Arvela OM, Wise GA.

Prince of Wales Children's Hospital, Randwick, Australia.

A review of the clinical findings in six infants with nutritional vitamin B12 deficiency seen during the last 10 years was undertaken and an attempt made to obtain long-term neurologic follow-up. There was a consistent clinical pattern in vitamin B12-deficient infants; irritability, anorexia, and failure to thrive were associated with marked developmental regression and poor brain growth. Two of the four patients who qualified for long-term review had a poor intellectual outcome. Although early response to treatment is satisfying, the long-term consequences of nutritional vitamin B12 deficiency in infants emphasize the need for prevention or early recognition of this syndrome.