J Tongji Med Univ. 1992 ; 12(4): 209-15.

Effects of electroacupuncture of "zusanli" acupoint on high blood pressure and blood hyperviscosity in stress rats.

Jin YX, Fu Q, Guo XQ.

Department of Physiology, Shanghai Medical University.

Elevation of blood pressure (BP) and blood viscosity (BV) was induced in unanesthetized Wistar rats by fixing and hanging. Electroacupuncture of "Zusanli" acupoint or microinjection of GABA (60 micrograms/10 microliters) into the IV ventricle of the brain could lower the high BP and BV induced by fixed-hanging, which could be blocked by a microinjection of GABAA receptor antagonist bicuculline (60 micrograms/10 microliters). The results showed that the depressant effect of electroacupuncture of "Zusanli" acupoint on high BP and blood hyperviscosity induced by fixed-hanging might be mediated by the activation of GABAA receptors in the brain.