Chronobiological Aspects of Mineral Water Drinking

Journal/Book: In: T. HIROSHIGE S. FUJIMOTO & K. HOMNA (Eds.): Endocrine Chronobiology. Hokkaido University Press Sapporo Japan 1992 pp. 64-72.. 1992;

Abstract: Institut für Arbeitsphysiologie und Rehahilitationsforschung University Marburg/Lahn F. R. G. Introduction High fluid intake and mineral water cures may affect autonomous functions. e.g. hormonal responses (1 10) activation of inflammatory processes (11) and adaptive modifications of hematological as well as renal parameters (2 7 9). Non-specific stimuli are able to modify spontaneous rhythms such as the circadian rhythm and to evoke adaptive responses with a periodic time structure (6). In a series of studies we investigated both the modifying influence of high fluid intake (especially of mineral waters) on the circadian rhythm of the cortisol excretion and the time structure of the response of the adrenal cortex to 4-week daily intake of mineral waters. Results 24-h experiments The modifications of circadian rhythms of endocrine and renal functions were investigated in healthy male subjects under constant resting conditions in a climatic chamber. Each experiment lasted 25 hours. The diet consisted in equally distributed low-protein meals which were administered in 3-hour intervals. The different test fluids were given with the meals and had to be taken within 10 minutes. In order to compare the different test-conditions intraindividually every test-person had to undergo three of these experiments with different test fluids or amounts of tap water respectively. To avoid adaptive modifications the intervals between the single experiments amounted one week at a minimum. Urine samples were collected in 3-hour intervals and among others analyzed for the cortisol content (TDx-Analyzer ABBOT). Under these conditions the cortisol excretion exhibited a clear cut circadian rhythm (Fig. 1) with maximum values in the forenoon and the minimal excretion during the night (5). . . .

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