Angew Parasitol. 1991 Feb; 32(1): 7-9.

[The effect of an extract from Cochlospermum angolense ("Burututu") on Plasmodium berghei in the mouse malaria suppression test]

Presber W, Herrmann DK, Hegenscheid B.

Often existing cross-resistance to structure analogous antimalarials causes the need to find new active compounds against malaria parasites. For this purpose the traditional medicine of tropical countries has proved to be a treasury. A root extract of Cochlospermum angolense showed in vitro a remarkable activity against Plasmodium berghei in the DNA synthesis measurement with 3H-labelled hypoxanthine. This effect could be reproduced under in vivo conditions with the "4-day suppressive test" of rodent malaria.