Farmakol Toksikol. 1991 May-Jun; 54(3): 12-4.

[The analgetic activity of antidepressants and their influence on the pain-relieving effect of acupuncture]

Ignatov IuD, Vasil'ev IuN, Kolchin VV, Amelin AV, Li Ch Kh.

The analgesic properties of new Soviet-made antidepressants pyrasidol, incazan, tetrindol as compared with amitriptyline and their influence on the analgesic effect of acupuncture were studied in experiments on rats by using the method of electrical stimulation of the tail root with stimuli of the increasing intensity. All the studied drugs at single and subchronic (6 days) administration possessed the analgesic actions. Pyrasidol exerted the most pronounced effect. The antidepressants enhanced the analgesic effect of electroacupuncture, in particular during activation of the points of general action and this effect showed up to the greatest degree under medication with pyrasidol.