Selenkonzentrationen in Vollblut und Serum bei Patienten mit chronischer Polyarthritis und Spondylitis ankylosans

Author(s): Bayer, W., Dettmer, N., Schmidt, K.

Abstract: The serum selenium and the whole blood selenium of a normal group (n = 53), of patients with spondylitis ancylosans (Sp. a. n = 22), of patients with rheumatoid arthritis (c. P. n = 50) and also the inflammation parameters (BSG, Fe, Cu, CRP) were determined.The selenium concentrations have been compared with selenium concentrations and glutathione peroxidase activity arrived at by a finnish study.Patients with rheumatoid arthritis clearly showed lower selenium concentrations in whole blood and particularly in serum as opposed to the normal group and patients with spondylitis ancylosans; selenium concentrations in the normal group were strongly under the levels described by one finnish study.The lower selenium levels induce a reduced glutathione peroxidase activity. Patients with rheumatoid arthritis were seen to have higher inflammation activities as patients with spondylitis ancylosans, these patients also have the lower selenium levels.The question is whether the inflammation process is as a consequence of reduced selenium deficiency inflammation defence exacebated, or a consumption of seleniumgroups by high degree inflammation takes place.

Keyword(s): Glutathion-Peroxidase

Zurück | Weiter