J Ethnopharmacol. 1990 Mar; 28(3): 357-63.

Effects of shosaikoto, an oriental herbal medicinal mixture, on restraint-stressed mice.

Amagaya S, Ogihara Y.

Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Nagoya City University, Japan.

Restraint-induced stress produced an inhibition of humoral immune responses accompanied by a decrease of rectal temperature and motor activity. Diazepam and levamisole restored the decrease of humoral immune responses. Furthermore, diazepam restored the decrease of rectal temperature. Shosaikoto, an oriental herbal medicinal mixture, restored the stress-induced inhibition of humoral immune responses and rectal temperature.