Zhong Xi Yi Jie He Za Zhi. 1990 Oct; 10(10): 590-2, 579-80.

[Effects of longevity-antihypertensive-mixture on essential hypertension and left ventricular hypertrophy]

Wei M, Chen KJ.

Geriatrics Institute, Xiyuan Hospital, China Academy of TCM, Beijing.

A study which enrolled 65 middle-aged and elderly essential hypertensive patients with Kidney-deficiency pattern was carried out to evaluate the effects of Longevity-Antihypertensive-Mixture (LAM). As LAM was composed of Kidney-tonifying herbs, all the subjects chosen fell into the pattern of Kidney-deficiency in TCM. The subjects were randomized into two groups: The LAM group had 34, and the control group taking Apocyhum Venetum L. Fluid (AVLF) 31. The duration of medication was 12 weeks. The main results were as follows: (1) At the end of week 4, the supine systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean blood pressure (MBP) in LAM group declined from 171 +/- 16 (mmHg, the same below), 101 +/- 6 and 127 +/- 7 to 153 +/- 12, 93 +/- 7 and 113 +/- 7 respectively. At the end of week 12, the supine SBP, DBP and MBP were 151 +/- 14, 93 +/- 6 and 112 +/- 8. There was significance of difference in the reduction of supine blood pressure compared with baseline (P less than 0.001). AVLF produced similar changes in the reduction of supine SBP, DBP and MBP. However, the magnitude of reduction in SBP and MBP was smaller than those with LAM (P less than 0.001). (2) There was no significance of difference in attaining goal blood pressure between LAM and AVLF groups (P greater than 0.05). At the end of week 4, 79.41% and 77.42% were achieved respectively; at 12, 79.41% and 80.65%. (3) LAM had stronger effect on relieving symptoms of essential hypertension and Kidney-deficiency than AVLF (P less than 0.05). (4) In LAM group the left ventricular mass index (VMI) decreased from 114.75 +/- 42.40 g/m2 to 100.39 +/- 36.08 g/m2 (P less than 0.001). The LVMI in AVLF group increased from 117.27 +/- 36.90 g/m2 to 117.68 +/- 38.37 g/m2 (P greater than 0.05). The results supported the therapeutic principle of TCM: Treating patients according to their pathophysiological patterns.