Effect of Echinacea purpurea extracts on fibroblast populated collagen lattice contraction

Author(s): Wijk, v. , R

Journal/Book: Phytotherapy Research. 1990; 4 (2): 77-81.

Abstract: The fibroblast populated collagen lattice was used to study the influence of extracts from roots or herbal parts of Echinacea purpurea an the collagen contracting ability of C3H10T1/2 mouse fibroblasts. Collagen gel contraction was inhibited by herb and root extracts which were added at the time of preparation of the gel. Inhibition was dependent an the amount of extract, the initial cell density and the collagen concentration used for preparation of the gel. When cell density was increased or collagen concentration decreased, the resulting increase in contraction counteracts the inhibitory effect of root extracts strongly, and that of herb extracts to a much lesser extent. The addition of extracts 1 h after preparation of the gel could hardly prevent contraction. Echinacea extracts inhibited the cell morphological changes which are characteristic for fibroblasts contracting a collagen gel. The inhibition of morphological changes parallels the inhibition of collagen gel contraction in many respects. The significance of these observations is discussed in relation to the process of wound healing.

Keyword(s): collagen

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