J Ethnopharmacol. 1989 Oct; 26(3): 249-54.

Effect of Trigonella foenum-graecum and Ammi majus on calcium oxalate urolithiasis in rats.

Ahsan SK, Tariq M, Ageel AM, al-Yahya MA, Shah AH.

Research Centre, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

The present study was undertaken to investigate the effect of Trigonella foenum-graecum seed and Ammi majus fruit on experimentally-induced kidney stones. Oxalate urolithiasis in male rats was produced by the addition of 3% glycolic acid to their diet. After 4 weeks, highly significant deposition in the kidneys was noticed and changes in water intake and body weight recorded. Daily oral treatment with T. foenum-graecum significantly decreased the quantity of calcium oxalate deposited in the kidneys thus supporting its use in Saudi folk medicine. The effects obtained by A. majus were, however, not significant.