Am J Obstet Gynecol. 1989 Jun; 160(6): 1447-53.

Preeclampsia: a hyperdynamic disease model.

Easterling TR, Benedetti TJ.

Department of Obstetrics and Gynecology, University of Washington, Seattle.

Preeclampsia is a common disease and as such is a significant contributor to maternal and neonatal morbidity and mortality. Despite the ubiquity of the disease and its public health impact, no comprehensive mechanism has been established. Therapy has been limited to bed rest and premature delivery. The purpose of this article is to examine preeclampsia from a hemodynamic point of view and to advance a hypothesis of disease mechanism.