Wallerian degeneration induces Ia-antigen expression in the rat brain

Journal/Book: J-Neuroimmunol 25 (2-3), 151-159. 1989;

Abstract: Strong expression of class II major histocompatibility (MHC II, Ia)antigens was observed in areas of Wallerian degeneration followingeither a cryoinjury to the cerebral and cerebellar cortex or unilateraleye enucleation in adult Wistar and Lewis rats. The Walleriandegeneration was disclosed by the Fink-Heimer method but not by routinehistological examination. The Ia antigens were localized exclusively tothe cells labeled with OX-42 antibody and mistletoe-1 lectin (ML-1) andpossessing the morphological identity of microglia. Development ofIa-expressing microglia at the sites of Wallerian degeneration wasaccompanied by neither tissue permeation of serum components as assessedby immunohistochemistry for autologous albumin nor tissue migration ofhematogenous inflammatory cells. Author.

Keyword(s): ANIMAL

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