Die Rolle der Serumeiweiße bei der Ultraviolettbestrahlung des Blutes (UVB) - neuere experimentelle Resultate und theoretische Zusammenhänge

Author(s): Segal, J.

Journal/Book: Erfahrungsheilkunde. 1989; 38/4: 219-222.

Abstract: The irradiation of patients blood by UV rays of 254 nm results. among other effects, in the breaking of the weak hydrogen bonds between the two antiparallel half-molecules of the serum albumin. releasing two halfmolecules with a highly increased dipole moment. The physicochemical evidence of this effect is put forward. These halfmolecules bind themselfs by their positive pole to the external face of cell membranes, thus inducing an anelectrotonic effect which inhibits the excitation. In the case of anoxic erythrocytes. swollen up to their double volume by the uptake of water due to a pH drop. the anodic effect results in a shrinking of the cells and an easies passage through, he capillaries. That may explain the therapeutical effect an arterial occlusions. The effect of the irradiated albumin upon the excitation level is demonstrated by the evolution of tumors in mice inoculated by Ehrlich's Ascites cells, previously hyperstimulated by UV irradiation, and developping tumors with a high purcentage of necrotic cells. The injection, one day after inoculation, of normal serum albumin does not change the course of' the disease, while previously irradiated albumin inhibits dramatically the necrotic evolution.

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