Epilepsy Res. 1988 Sep-Oct; 2(5): 337-9.

Inhibitory effect of a mixture of herbal drugs (TJ-960, SK) on pentylenetetrazol-induced convulsions in E1 mice.

Sugaya E, Ishige A, Sekiguchi K, Iizuka S, Sugimoto A, Yuzurihara M, Hosoya E.

Department of Physiology, Kanagawa Dental College, Yokosuka, Japan.

TJ-960 is a spray-dried mixture of 9 herbal drugs. The convulsions of E1 mice induced by pentylenetetrazol (18 mg/kg) were completely inhibited by p.o. administration of TJ-960 at a daily dose of 1.0 g/kg both in 8-week-old and 4-week-old E1 mice. These findings suggest that TJ-960 has an inhibitory effect on the convulsions of this hereditary animal model of epilepsy.