Anticonvulsive action of gelsemium, ignatia, sempervirine, srychnine dilutions in rats

Author(s): Narcisse, G., Guillemain, J. , Huguet, F.

Journal/Book: Proc GIRI. 1988; 2: 2.

Abstract: Various studies have shown the convulsive effect of a single or repeated treatment with inverse agonists or antagonists of benzodiazepin in rats. Given the clinical "indications" for Ignatia and previous results concerning convulsions caused by strychnine, we have studied an eventual protector effect of low concentrations of Ignatia compared to another substance with anxiolytic activity (Gelsemium) and to each of their major active principals( strychnine and sempervirine) . The study was carried out on 6 lots of 10 Sprague- Dawley rats housed under controled conditions. The control lot received pure-for-injection (p.f.i) water, the other animals were treated with an antagonist of benzodiazepin (RO 15-3505, 0.5 mg/kg) twice daily by the i.v. route for 22 to 24 days consecutively. These same animals were given the different homeopathy treatments at a 5 CH dilution or p.f.i water prepared under the same conditions at noon. The convulsive agent (Izoniazid, 350 mg/kg s.c.) was administered 18h after the last treatment with RO 15-3505 and 2h after receiving the homeopathic preparation. Except for the control lot, the study was carried out under blind conditions using coded solutions. RO 15-3505 increased the number of clonic convulsions( NS) as compared to the pfi water control and their intensity (p<0.05) according to a 1-3 scale. The different treatments caused a decrease (NS) in the number of clonic convulsions and their intensity compared to RO controls. Only the SCH dilution of Ignatia significantly decreased (p<0.05) the number of maximum scores compared to the RO controls.

Keyword(s): hom. br. exp. anim. gelsemium. ignatia. strychninum. sempervirin.

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