Immunomodulatory acitvity of low doses of interferon in mice

Author(s): Dorfman, P., Bastide, M.

Journal/Book: Biomed and Pharmacother. 1988; 42: 197-206.

Abstract: We evaluated the immunomodulatory effects of mouse interferon (1 FN) a,b on the specific humoral response of mice (OFI) to sheep erythrocytes and on cell-mediated immunity by studying the cytotoxic activity of allospecific T-cells (CTL) and natural killer (NK) cells. Four injections of 2 IU of IFN before administration of the antigen did not have an effect on the humoral response, whereas 4 injections of 2 x 10-10 IU of IFN caused a significant increase in the number of antibody-secreting cells. When C57BL/6 mice were treated with 5 injections of 2 IU or 2 x 10-10 IU of IFN before the scone immunization with allogeneic cells, the CTL activity was not modified; but when the mice were also treated with 2 x 10-10 IU 3 times after immunization, this activity was strongly stimulated. IFN caused a decrease in the activity of CTL from NZB at both doses. The cytotoxic response of NK cells was stimulated by 5 injections of 2 IU of IFN in both strains of mice. The results of our study suggest that very low doses of IFN a,b have immunopharmacologic activity.

Keyword(s): interferon

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