Zur Pharmakologie von g-Strophanthin

Journal/Book: therapeutikon. 1988; 2:

Abstract: The present pharmacodynamic and pharmacokinetic information an oral g--strophanthin therapy makes it evident that neither insistence an as high a rate of absorption of orally administered g--strophanthin as possible nor reservations with regard to this medication owing to the minimal absorption and its large vari-ation as well as the danger to the patient possibly resulting from this can do justice to the real claim of this therapy. It is not rates of absorption in terms of the defini-tion (absorption is the uptake of sub-stances through the skin or mucosa into the bloodstream and lymphatic circula-tion) which are the parameters to be determined here, but the temporarily and quantitatively adequate occupation of a specific receptor an the target organ by the drug. If the methods of detection used so far for exact determination of systemic bioavailability provided inade-quate results, this is due not least to the nature of the strophanthin molecule, the high polarity of which greatly limits per-meation when it has not yet passed the lipoid barrier, and has a major promoting effect an evasion when it has passed this barrier.

Keyword(s): Strophanthin-Pharmakologie

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