Hepatoprotective and Immunomodulatory Effects of Antioxidant Therapy

Author(s): Deak, G., Nekam, K., Müzes, G., Gonzalez-Cabello, R., Gergely, P., Feher, J.

Journal/Book: Acta Medica Hungarica. 1988; 45/3-4: 287-295.

Abstract: The hepatoprotective and immunomodulatory effects of silymarin and amino-imidazole-carboxamide-phosphate were studied in 40 patients with alcoholic cirrhosis of the liver in a one-month double-blind clinical trial. Treatment with either of the drugs normalized the elevated levels of aspartate aminotransferase, alanine aminotransferase and serum bilirubin, markedly reduced the high level of gamma-glutamyl trasferase, increased lectin-induced lymphoblast transformation, decreased the percentage of OKTß+ cells and suppressed lymphocytotoxicity. None of these changes occurred in the placebo-treated group. Thus, the hepatoprotective effects of silymarin and amino-imidazole-carboxamide-phosphate in alcoholic cirrhosis can partly be attributed to the immunomodulatory activity of the drugs.

Keyword(s): silymarin

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