Effect of Ocimum sanctum Linn. on humoral immune responses

Author(s): Dewan, V., Bhattacharya, S., Gupta, V., Maiti, P., Sen, P.

Journal/Book: Indian Journal of Medical Researche. 1988; 87: 384-386.

Abstract: The effect of O. sanctum (Tiriasi) an the humoral immune responses in experimental animals was studied. O. sanctum enhanced anti-SRBC haemagglutination titre and IgE antibody titre, as measured by passive cutaneous anaphylaxis in rats. Antigen-induced histamine release from peritoneal malt cells of sensitised rats in vitro was significantly inhibited by O. sanctum, which also antagonised responses to various spasmogens an isolated guineapig ileum. Thus, it appears that O. sanctum modulates the humoral immune responses by acting at various levels in the immune mechanism such as antibody production, release of mediators of hypersensitivity reactions and tissue responses to these mediators in ~ the target Organs.

Keyword(s): Octimum sanctum

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