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August 2021

J Ethnopharmacol. 1987 Sep-Oct; 21(1): 75-84.

Structure and chemotherapeutical activity of a polyisoprenylated benzophenone from the stem bark of Garcinia huillensis.

Bakana P, Claeys M, Totté J, Pieters LA, Van Hoof L, Tamba-Vemba , Van den Berghe DA, Vlietinck AJ.

Ecole de Pharmacie, Université de Kinshasa, Zaïre.

The stem bark of Garcinia huillensis grown in Zaïre and used in central-African traditional medicine has been subjected to a bioassay-guided fractionation. The chemotherapeutically active petroleum ether extract afforded fatty acids, aliphatic alcohols, triterpenes and a polyisoprenylated benzophenone, which was identified as garcinol, also named camboginol. This compound has been shown to exhibit chemotherapeutical activity gram-positive and gram-negative cocci, mycobacteria and fungi. On the other hand garcinol has been found to be inactive against gram-negative enteric bacilli, yeasts and viruses.


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