Rev Fr Gynecol Obstet. 1987 Apr; 82(4): 221-7.
[Treatment of mastopathies with cyclic mastodynia. Clinical results and hormonal profiles]
The therapeutic effect of a long-term Gestagen therapy (lynestrenol) and a phytotherapy (Mastodynon) in comparison to a placebo group is reported in 160 cases of severe mastopathy with cyclic mastalgia. In 82.1 percent of the patients in the gestagen-group and in 74.5 percent of the patients in the Mastodynon-group a good relief of the premenstrual symptoms was achieved. In the placebo group only 36.8 percent of the patients reported a relief of symptoms. The difference is significant. The evaluation and analysis of serum HPRL and serum-progesterone showed a significant rise of the HPRL-level and a significant decrease of the progesterone-level. Because of this severe influence on the endocrine balance the recommendation for an alternative phytotherapy prior to a long term gestagen therapy is justified.