Biological properties of PYRULARIA thionin prepared from nuts of PYRULARIA PUBERA

Journal/Book: Toxicon 24 (6), 622-625. 1986;

Abstract: Pyrularia thionin is a 47 amino acid basic peptide which resembles wheatpurothionin and mistletoe viscotoxin. It is toxic to mice, with an LD50of 1.5 mg/kg body weight and is cytotoxic to tumor and normal cells inculture, with ID50 values ranging from 0.62 to 17 micrograms/ml. Againstseven bacterial species it was toxic only to Micrococcus luteus. Thetoxin did not protect mice against transplanted B16 melanoma, nor did itshow any mitogenic activity with mouse spleen lymphocytes. Author.

Keyword(s): ANIMAL

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