Biological properties of PYRULARIA thionin prepared from nuts of PYRULARIA PUBERA
Journal/Book: Toxicon 24 (6), 622-625. 1986;
Abstract: Pyrularia thionin is a 47 amino acid basic peptide which resembles wheatpurothionin and mistletoe viscotoxin. It is toxic to mice, with an LD50of 1.5 mg/kg body weight and is cytotoxic to tumor and normal cells inculture, with ID50 values ranging from 0.62 to 17 micrograms/ml. Againstseven bacterial species it was toxic only to Micrococcus luteus. Thetoxin did not protect mice against transplanted B16 melanoma, nor did itshow any mitogenic activity with mouse spleen lymphocytes. Author.