Studies on the standardization of mistletoe preparations

Journal/Book: Oncology 43: suppl. 1, 16-22. 1986;

Abstract: The newly isolated phenylpropanoids syringin,syringenin-apiosylglucoside, eleutheroside E and the high molecularlectins and viscotoxins were selected for a standardization of mistletoeextracts and drug preparation. The phenylpropanoids found in allalcoholic and aqueous extracts were suitable for an HPLC fingerprintanalysis, and for quantitative determination. The lectin content of thedrug preparations was determined by single radial immunodiffusion. Asshown by the isoelectric focussing method, Iscador and fermentedmistletoe extracts contain only the mistletoe lectins ML II/III, whereasthe proteins of the ML I complex are missing. For identification andquantitative determination of viscotoxins, an HPLC method was designed.Author.

Keyword(s): CHROMATOGRAPHY-AFFINITY

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