Oral Vaccination enhances Phagocytic Functions - Die Erhöhung von Phagozytose-Aktivitäten durch orale Vakzination

Author(s): Chan, G., Rusch, V.

Journal/Book: Mikroökologie und Therapie. 1986; 16: 297-301.

Abstract: Previous studies from our laboratories have demonstrated a protective effect of orally administered, viable bacteria an mice. Specifically, per os administration of 107 non-pathogenic Streptococcus faecalis or Escherichia coli every day for 2 to 3 weeks increases the resistance of random bred white mice to challengc with Salmonella typhimurium or Haemophilus influenzae. We have evaluated various parameters of innate and acquired immunity in an effort to ascertain the biological basis of this enhancement of resistance. This report deals with the natural killer cell (NK) and phagocyte functions of animals which have received viable Streptococcus faecalis as a component of their drinking water for a period of at least 3 weeks. We have noted that the NK cell activity is unchanged by such treatment, while the neutrophilic white blood cells exhibit enhanced phagocytic activity. The intracellular killing of an unrelated organism, Staphylococcus aureus, is enhanced while the cells remain unable to exert a microbicidal effect of Salmonella typhimurium. No change in macrophage microbicidal activity has been noted. Chemotaxis was increased.

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