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October 2021

Lack of efficacy of garlic in patiens with hyperlipoproteinemia

Author(s): Lehmann-Leo, W., Möller, B., Martin, T., Schwartzkopff, W.

Journal/Book: Arzneimittel Forschung/ Drug Research. 1986; 36: 766-768.

Abstract: The effects of dried garlic an blood lipids apolipoproteins and blood coagulation parameters in hyperlipemic patients were studies in two controlled, randomized, double-blind studies. Both studies comprised placebo and therapy periods of 6 weeks each. The doses administered were 3 x 198 mg in Study 1(34 patients) and 3 x 450 mg in Study 11 (51 patients). In both studies, the following serum parameters were measured every 3 weeks: total cholesterol, HDL (high density lipoprotein)- and LDL (low density lipoprotein)-cholesterol, triglycerides and 'several safety Parameters. In addition, apolipoproteins A and B, euglobulin lysis time, fibrin split products, prothrombin time, whole blood coagulation time and fibrinogen levels were determined in the. second study only.The results: indicated that neither dosage of dried garlic showed any_significant effect on any of the parameters measured. It is therefore concluded that, if there is any effect of garlic´ on the parameters measured, it is not apparent when using a dried preparation in the dosage studied.

Keyword(s): Apoproteins A and B

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