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August 2022

Study of the long-term action of a Ginkgo biloba extract on vigilance and mental performance as determined by means of quantitative pharmaco-EEG and psychometric measurements

Author(s): Voelp, A., Klasser, M.

Journal/Book: Arzneimittelforschung. 1985; 35: 1459-1465.

Abstract: The action of a Ginkgo biloba extract (rökan®, Tanakan®, G.B.E) in promoting blood flow has been demonstrated in several animal and human pharmacological studies. The aim of this present study was to estimate the action of the substance an the central nervous system in order to be able to assess its potential use as a therapeutic agent in geriatric patients with cerebral insufficiency. Quantitative pharmacy-EEG is the method of choice for studying the vigilance-promoting effects of a drug. It is incomparable for confirming the findings of behavioural and psychometric studies. 60 volunteers of either sex participated in the double-blind trial. They were aged 57-77 years and showed mental deterioration corresponding to their age. They were randomly di-vided into three experimental groups: 20 subjects received 3 x 40 mg/day G.B.E., 20 received 5 mg nicergoline and 20 received a placebo of similar appearance. The subjects un-derwent an extensive series of examinations before and 4, 8 and 72 weeks after the start of medication. Analysis of the EEG results for the whole group revealed no significant advantage of G.B.E over the two reference sub-stances with regard to vigilance. However, a sub-classification of the subjects showed that the vigilance of those persons with a more unfavourable initial situation chronic G.B.E. medication. This increase in vigilance was reflected at the behavioural level by an improvement of reaction times in the G.B.E. group by comparison with the reference substances.The results show that chronic G.B.E. medication has a positive effect in geriatric subjects with deterioration of mental performance and vigilance, and this effect is reflected at the behavioural level. In contrast, hardly any improvement can be achieved in healthy subjects with a good initial state.

Keyword(s): Encephalotropic drugs

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