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January 2023

Monoclonal antibodies block the bromelain-mediated release of human placental alkaline phosphatase from cultured cancer cells

Author(s): Millan, J., Klier, F., Fishmann, W.

Journal/Book: Published by Elsevier Science Publishers BN(Biomedical Division). 1985; 179:

Abstract: Certain monoclonal antibodies (mAbs) to human placental alkaline phosphatasc (PLAP) block bromelain cleavage of a 2--kDa segment from each of the two polypeptide chains of PLAP. These mAbs serve the release of PLAP from cultured cancer cell surfaces by bromelain. Such proteolysis-blocking mAbs serve as tools to specifically modify the molecular topography of cell surfaces by protease treatment.

Keyword(s): Alkaline phosphatase

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