A New Statistical Procedure for Testing Equivalende in Two-Group Comparative Bioavailability Trials

Author(s): Anderson, S.

Journal/Book: Journal of Pharmacokinetics and Biopharmaceutics. 1984; 12: 83-91.

Abstract: The clinical problem of testing for equivalence in comparative bioavailability trials is restated in terms of the proper statistical hypotheses. A simple t-test procedure for these hypotheses has been developed that is more powerful than the methods based an usual (shortest) and symmetric confidence intervals. In this note, this new procedure is explained and an example is given, including the method for sample size determination.

Keyword(s): bioavailability

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