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June 2019

Validity and treatment dilution in Zelen's single-consent design

Journal/Book: Statistics in Medicine. 1984; 3: 215-218.

Abstract: Employing randomization theory, this note examines the manner in which a clinical trial employing Zelen's randomized consent design yields an estimated treatment effect free of selection bias. We also examine the concept of ´treatment dilution' in this design.

Keyword(s): Randomized clinical trial


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