Lasers Surg Med. 1982 ; 2(2): 187-98.

Transventricular revascularization by laser.

Mirhoseini M, Muckerheide M, Cayton MM.

Transventricular acupuncture or revascularization by the method of producing channels between the ventricular cavity and the ischemic myocardium has challenged several investigators. The concept of producing these channels using high-energy CO2 laser was based on the finding that the laser beam could produce small channels devoid of debris, and fibrosis would not occur. Four groups of mongrel dogs with six animals in each group were studied. In three groups the left anterior descending (LAD) branch of the coronary arteries was ligated above the first diagonal, and channels were made in the myocardium according to the protocol for each group. The fourth group was the control, the LAD was ligated but the myocardium was not exposed to laser treatment. In the control group all animals died within 20 minutes of LAD ligation. Animals in the other groups survived ligation with laser, and were subsequently sacrificed at varying intervals. At autopsy the epicardial component of the channels was visible. Penetration through the myocardium could be demonstrated. Microscopically the channels were patent and endothelialized. Further investigations are in process, but we believe laser channels protect and nourish the ischemic myocardium.