Biull Eksp Biol Med. 1980 May; 89(5): 527-9.

[Effect of stimulation of antinociceptive brain zones on the analgesic effect of electroacupuncture in rats]

Vasil'ev IuN, Ignatov IuD, Andreev BV, Kachan AT, Bogdanov NN.

It was shown in experiments on freely moving rats that electroacupuncture (EA) depresses the emotional-behavioral response to the nociceptive stimulation of the tail. Analogous changes in the pain reaction pattern arose during electric stimulation of the central grey matter and posterior parts of the lateral hypothalamus. In the presence of antinociceptive brain stimulation. EA was followed by strong potentiation of analgesia. Naloxon in a dose of 5 mg/kg removed the antinociceptive effect produced by stimulation of the deep brain structures and the analgetic effect of electroacupuncture. Potential mechanisms of the realization of the acupuncture effect are discussed.