Inhibition of protein synthesis by a toxic lectin from VISCUM ALBUM L.(mistletoe)

Journal/Book: Biochem. J. 190, 843-845. 1980;

Abstract: 1. The haemagglutinating and toxic lectin from Viscum album L.(mistletoe) inhibits protein synthesis in a lysate of rabbitreticulocytes, with an ID50 (concentration giving 50% inhibition) of 2.6microgram/ml. This effect is enhanced (ID50 0.21 microgram/ml) if thelectin is reduced with 2-mercaptoethanol. 2. The lectin inhibits proteinsynthesis also in BL8L cells in culture. Inhibition occurs after a lagtime of 3 h. The ID50 is 7 ng/ml, and increases after reduction of thelectin. 3. This and the gross lesions observed in rats poisoned with V.album lectin indicate this is a toxin very similar to ricin. Author.

Keyword(s): ANIMAL

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