Am J Psychiatry. 1979 Mar; 136(3): 297-302.

Acupuncture treatment of schizophrenia: report on three cases.

Kane J, Di Scipio WJ.

The authors conducted a 9-week blind controlled study of the effects of acupuncture on schizophrenic illness in three patients on an inpatient ward of a psychiatric hospital. This paitents were used as their own controls. The authors compared the effects of acupuncture, pseudo-acupuncture (random needling), and no treatment control periods. Two patients who had had florid schizophrenic symptoms responded positively to true acupuncture treatment and negatively to pseudo-acupuncture. The third patient, whose symptoms were primarily affective-depressive, showed no significant response to treatment. The authors explore the mechanisms thought to be involved in the etiology of schizophrenia, focusing on the cortical arousal hypothesis.