J Pharm Sci. 1977 Aug; 66(8): 1194-5.

Antitumor agents XXIII: Helenalin, and antitumor principle from Anaphalis morrisonicola HAY.

Lee KH, Haruna M, Huang HC, Wu BS, Hall IH.

A chloroform extract of the whole plant of Anaphalis morrisonicola HAY, showed significant antitumor activity against Ehrlich ascites carcinoma, Walker 256 carcinosarcoma, and P-388 lymphocytic leukemia. Systematic fractionation of the extract led to isolation and characterization of helenalin, a pseudoguaianolide, as the major active principle.