Ueber die kanzerostatischen und immunogenen Eigenschaften von Mistelproteinen

Journal/Book: Krebsgeschehen 5, 106-114. 1977;

Abstract: A product with cancerostatic and immunogenic properties has beenisolated from Viscum album. The substance is a pure protein, consistingof 10 components: undenatured, it has exhibited the following actions:tumor inhibition and prolongation of survival in certain in-vivoexperiments in animals: stimulation of thymus growth in healthy animals,reduction of thymus regression in tumor-bearing animals: stimulation ofDNA synthesis of thymus cells in vitro: specific inhibition of RNA andDNA synthesis of various tumor cells, no inhibition of normal bonemarrow, spleen and thymus cells: selective affinity for polynucleotidesand a positive RNA binding test of at least two components. As regardseventual clinical use, the action spectrums of these substances, and themechanisms of action to be deduced from them justify the hope that theymay lead to a supplementary therapy that is both cancerostatic andimmuno-stimulating. This would be especially valuable for the preventionof recurrences and metastases. The tumor specificity observed in vitro,and the fact that the dose range is several hundred or thousand timeslower than that of the cytostatics currently used in tumor therapy,indicate a biologically relevant mechanism of regulation cellularinformation. Elucidation of this mechanism will probably remainfragmentary, however, the more so since experimental models in animalsare inadequate for this purpose. Two of the problems that remain to besolved are: whether the marked stimulation of the thymus and the strongimmunogenic action are correlated with the observed prophylactic actionagainst implanted tumors, or whether two parallel effects are involved,and the possible correlation between these phenomena and the in-vitroinhibition of RNA and DNA synthesis.COPYRIGHT BY Elsevier Science BV, Amsterdam, Netherlands END OF DOCUMENT

Keyword(s): plant

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