J Clin Pharmacol. 1975 Feb-Mar; 15(2-3): 139-43.

Analgesic effect of delta-9-tetrahydrocannabinol.

Noyes R, Brunk SF, Baram DA, Canter A.

A preliminary trial of oral delta-9-tetrahydrocannabinol (THC) demonstrated an analgesic effect of the drug in patients experiencing cancer pain. Placebo and 5, 10, 15, and 20 mg THC were administered double blind to ten patients. Pain relief significantly superior to placebo was demonstrated at high dose levels (15 and 20 mg). At these levels, substantial sedation and mental clouding were reported.