Orale Immunisierung mit nichtvermehrungsfähigen Mikroorganismen oder ihren Antigenen

Author(s): Graben, N., Funk, J., Sahm, E., Raettig, H.

Journal/Book: Zbl Bakt Hyg, I. Abt Orig A. 1971; 218: 93-104.

Abstract: In earlier tests we demonstrated that live phages and Col-SK-viruses as well as inactivated, radiomarked S. typhi murium bacteria after oral induction are persorbed by the intestine of the mouse and soon appear in the blood. Then we extended these experiments by three more test models: live staphylococci and S. typhi murium bacteria as well as C. albicans germs.Then the test organisms are persorbed rather independent an the replication state, the size, and the quantity of the test organisms. The time curves are so similar that there a generally valid norm curve of persorption kinetics in fig. 4 could he developed. This curve attains its climax between 30 and 60 min. after induction of the germs and declines to the nadir after 3 hours.If phages are induced by the intravenous route as test model they occur at the same speed in the opposite direction in the gastric contents; the curve of this secretion is very similar to that of the persorption. The courses of persorption are described as Herbst-effect by experiments of Volkheimer and co-workers. According to this, orally induced particles may be persorbed in the body up to a size of 50? paracellulary by the mucosal epithelium of the small intestine. In that way the oral vaccination becomes effective.

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