The Independence of Cell Division and Age-Dependent Modification of Enzyme Induction

Journal/Book: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 38 No. 6 1970. 1970;

Abstract: Fels Research Institute and Department of Biochemistry Temple University Medical School Phila. Pa. 19140 Received February 13 1970 SUMMARY The age-dependent modification of hepatic glucokinase inducibility was employed as a parameter of biological aging in the rat. Synchronous division of liver cells was induced by partial hepatectomy. Fully regenerated liver retained the pattern of enzyme inducibility characteristic of the untreated animal of the Same age. The age-dependent modification of enzyme inducibility in rat liver is unrelated to cell division and may reflect an aging phenomenon of extrahepatic origin. ___MH

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