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STUDIES OF THE EPIDERMAL WATER BARRIER PART II INVESTIGATION OF THE CHEMICAL NATURE OF THE WATER BARRIER*.

Journal/Book: THE JOUNRAL OF INVESTIGATIVE DERMATOLOGY VOI. 50 No. 1 1968. 1968;

Abstract: MATOLTSY A. G. M.D. A. M. DORNES M.Sc. † AND T. M. SWEENEY M.D. From the Department of Dermatology Boston University School of Medicine and Evans Memorial Department of Clinical Research. University Hospital Boston University Medical Center Boston Mass. This investigation was supported in part by Research Grant AM 05924 and Graduate Training Grant T 1-AM 5295 National Institute of Arthritis and Metabolic Diseases United States Public Health Service. Accepted for publication June 10 1967. † Present Address: C.S.I.R.O. Division of Animal Physiology Parramatta N.S.W. Australia. SUMMARY Skin samples from hairless mice were treated with reagents and the diffusion of water was determined to obtain information about the chemical nature of the epidermal water barrier. The flux of tritiated water was determined in diffusion chambers and changes in barrier function were evaluated by calculation of the ratio of the diffusion rates obtained prior to and alter application of the reagent. After application of chloroform ethylether acetone and DM


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