Non-enzymatic Transamination of Histidine with -Keto Acids

Journal/Book: SONDERDRUCK AUS DER ZEITSCHRIFT DIE NATURWISSENSCHAFTEN 54. JAHRG. 1967 H. 15/16 S. 443/44. 1967;

Abstract: Department of Chemistry University of Houston Texas Non-enzymatic transamination reactions between different -amino acids or between -amino acids and pyruvic acid or between -amino and glyoxalate or between glutamic acid and 3-hydroxy-pyridine-4-aldehyde have been reported [1 2]. Evidence is presented showing that transamination reactions at 85° C between histidine and any one of the keto acids viz. pyruvic acid oxaloacetic acid -ketoglutaric acid -ketoadipic acid or -ketopimelic acid can take place in the absence of vitamin B6 derivatives. The transamination reaction is catalyzed by aluminum or iron salts. The pH optimum is 4.0. Under the experimental conditions studied the equilibrium lies at about 37 % to 87 % conversion to the corresponding amino acid and imidazole-pyruvic acid. Among the various dicarboxylic -keto acids studied the optimum transformation is obtained with -ketoglutaric acid. . . .

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