Control of aldosterone secretion by change of body potassium in normal man

Journal/Book: Reprinted from: AMERICAN JOURNAL OF PYHYSIOLOGY Vol. 207 No. 1 July 1964 (Printed in U.S.A.). 1964;

Abstract: Clinical Endocrinology Branch National Heart Institute National Institutes of Health Bethesda Maryland GALAN DONALD S. CATHERINE S. DELEA JOHN R. GILL JR. J. PICTON THOMAS AND FREDERIC C. BARTTER. Control of aldosterone secretion by change of body potassium in normal man. Am. J. Physiol. 207(I): 104-108. 1964.-Seven normal subjects were subjected to depletion and repletion of body potassium an balance regimen. Aldosterone excretion plasma volume and arterial pressure were measured. Potassium depletion decreased and potassium repletion consistently increased aldosterone excretion. Changes in sodium balance were prevented by restricting dietary sodium or replacing lost sodium. The effects an aldosterone excretion were thus shown to be independent of reciprocal changes in sodium balance of intravascular volume or of arterial pressure. The results suggest that changes in body potassium influence aldosterone secretion by mechanisms independent of those responsive to changes in body sodium or fluid volume.

Keyword(s): potassium aldosterone adrenal cortex normal man

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