Monophage analysis of elm population

Journal/Book: Fao/ Forgen 63 (6b/4), 1-7. 1963;

Abstract: We demonstrated that a preparation of Viscum album (Iscador) has unusualeffects on the immune system. In CD-1 mice, the mean weight of thethymus increased from 45 to 85 mg. following six daily intraperitonealinjections of 2.5 mg. of Iscador. The thymic trophic influence wasmaintained over a long period of time. Sprague-Dawley rats treated withIscador for 16 weeks showed an increase of 78% in thymic weight overcontrols. The increased weight of the thymus was due to increasedproliferation of cortical thymocytes. The number of blast cells in theouter cortex of the thymus increased within 2 days of the firstinjection and remained at high levels. Thymocytes of Iscador-treatedanimals were 29 times more responsive to Concanavalin A than those ofuntreated controls. Iscador increased the amount of antibody produced byanimals injected with sheep red blood cells if it was injected after theantigen. Iscador also had effects on hematopoietic cells. It acceleratedthe recovery of hematopoietic tissue in bone marrow and spleens ofirradiated animals. We believe that V. album preparations may bevaluable reagents for perturbing thymus function. Author.

Keyword(s): ANIMAL

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